ID   BOSS_DROME     STANDARD;      PRT;   896 AA.
AC   P22815; Q9VBJ5;
DT   01-AUG-1991 (Rel. 19, Created)
DT   01-NOV-1997 (Rel. 35, Last sequence update)
DT   16-OCT-2001 (Rel. 40, Last annotation update)
DE   Bride of sevenless protein precursor.
GN   BOSS OR CG8285.
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7227;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=91115074; PubMed=2276620;
RA   Hart A.C., Kraemer H., van Vactor D.L. Jr., Paidhungat M.,
RA   Zipursky S.L.;
RT   "Induction of cell fate in the Drosophila retina: the bride of
RT   sevenless protein is predicted to contain a large extracellular
RT   domain and seven transmembrane segments.";
RL   Genes Dev. 4:1835-1847(1990).
RN   [2]
RP   REVISIONS.
RA   Kraemer H.;
RL   Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   SEQUENCE FROM N.A.
RC   STRAIN=Berkeley;
RX   MEDLINE=20196006; PubMed=10731132;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
RA   Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
RA   Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
RA   Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [4]
RP   FUNCTION.
RX   MEDLINE=91312442; PubMed=1857416;
RA   Kraemer H., Cagan R.L., Zipursky S.L.;
RT   "Interaction of bride of sevenless membrane-bound ligand and the
RT   sevenless tyrosine-kinase receptor.";
RL   Nature 352:207-212(1991).
CC   -!- FUNCTION: ACTS AS A LIGAND FOR SEVENLESS TYROSINE-KINASE RECEPTOR
CC       DURING EYE DEVELOPMENT.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein (Potential).
CC   -!- TISSUE SPECIFICITY: EXPRESSED EXCLUSIVELY BY R8 PHOTORECEPTOR
CC       CELLS AND IS INTERNALIZED IN A SEV-DEPENDENT MANNER BY R7 CELLS.
CC   --------------------------------------------------------------------------
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DR   EMBL; X55887; CAA39373.1; -.
DR   EMBL; AE003754; AAF56539.1; -.
DR   FlyBase; FBgn0000206; boss.
DR   GO; GO:0005902; C:microvillus; IDA.
DR   GO; GO:0005118; F:sevenless binding activity; IGI.
DR   GO; GO:0045466; P:R7 differentiation; NAS.
DR   GO; GO:0045470; P:R8-mediated photoreceptor organization; NAS.
DR   InterPro; IPR002956; Bride_of_7less.
DR   InterPro; IPR000337; GPCR_Mgr.
DR   Pfam; PF00003; 7tm_3; 1.
DR   PRINTS; PR01223; BRIDEOF7LESS.
KW   Transmembrane; Glycoprotein; Vision; Signal.
FT   SIGNAL        1     31       POTENTIAL.
FT   CHAIN        32    896       BRIDE OF SEVENLESS PROTEIN.
FT   DOMAIN       32    530       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    531    554       POTENTIAL.
FT   TRANSMEM    570    588       POTENTIAL.
FT   TRANSMEM    615    637       POTENTIAL.
FT   TRANSMEM    655    676       POTENTIAL.
FT   TRANSMEM    693    712       POTENTIAL.
FT   TRANSMEM    728    748       POTENTIAL.
FT   TRANSMEM    759    781       POTENTIAL.
FT   DOMAIN      782    896       CYTOPLASMIC (POTENTIAL).
FT   CARBOHYD    183    183       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD    307    307       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD    474    474       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD    485    485       N-LINKED (GLCNAC...) (POTENTIAL).
SQ   SEQUENCE   896 AA;  99950 MW;  580AEBC0FA208E24 CRC64;
     MKVMDALQSG RRKPLPVALL CILVTVFCVL ECHGADLTSP TKKSAPLRIT KPQPTSQQAK
     PISITTRAPT TVASTTDDEV SSSVDGQLAP LISSTTEGPS SGTTASLVPE ICLNGLQLTV
     NSADEGTVIR KQEEFVKILE GDVVLSVLTK DPDSALFVIN RVNQANLIMA DFEIGIRAIS
     IDNASLAENL LIQEVQFLQQ CTTYSMGIFV DWELYKQLES VIKDLEYNIW PIPGTRAHLF
     PKVAHLLHQM PWGEKIASVE IATETLEMYN EFMEAARQEH MCLMHFKSDD NVYIMFGNKL
     ASHFKENGTL FSVPTDRTDD EFLADLPNRA FVLMENEIDL STAVELDATP TALDEILIGK
     SVLPSRVLSF AGSIIDLMNW LRGSLSKHCK RGEEHDLYVL ESCFNFLNFI EDWRTSEYRQ
     AHDTAEILSL LLMRKLGTAM NFQMYQKKVL TLDKITGESR TELREIASQN FVTNVTTYYH
     YNRDNHTSLE LKTKFGQVFN CQYSAGDNRR YPFLFDGESV MFWRIKMDTW VATGLTAAIL
     GLIATLAILV FIVVRISLGD VFEGNPTTSI LLLLSLILVF CSFVPYSIEY VGEQRNSHVT
     FEDAQTLNTL CAVRVFIMTL VYCFVFSLLL CRAVMLASIG SEGGFLSHVN GYIQAVICAF
     SVVAQVGMSV QLLVVMHVAS ETVSCENIYY GRWLWGLLAY DFALLCCVGA LIPSIYRSQR
     NYREGILIVI GSVLIMVIWV AWIALSLFGD EWRDAAIPLG LQASGWAVLV GILIPRTFLI
     VRGIERSDIA QALPSLTSLA FAQNNQYSSE QSVYECVNPA MRHCSQDEVN HQSPSEIPTL
     PLRGGGPRRQ QFFANLRQAN ANINPQRPPP RPQQSPSRSS VSSLPPSPDH NKITRF
//